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KMID : 0861020170320040053
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Korea Journal of Herbology
2017 Volume.32 No. 4 p.53 ~ p.60
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Skin Wrinkle Improvement Effect of Paeoniae radix and processed Paeoniae radix Through inhibition of Advanced glycation end products (AGEs)
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Kim Su-Ji
Lee Ah-Reum
Kim Soo-Hyun
Kim Kyeong-Jo
Kwon Oh-Jun
Choi Joon-Young
Koo Jin-Suk
Roh Seong-Soo
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Abstract
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Objectives：Collagen decrease of Skin appears through various path ways. One of causes may be the Advanced glycation endproducts (AGEs) that combine formation of glucose and protein. The aim of this study was to explore the prevent wrinkle formation of Paeoniae radix (PR) and heated Paeoniae radix (HPR) via AGEs path way.
Methods：AGEs formation inhibitory activities of PR and HPR measured using bovine serum albumin, glucose, and fructose. To evaluate the protective effects of PR and HPR in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rat were distributed into four groups. Normal rats (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 ㎎/㎏ PR(PR), AGEs-induced rats treated with 100 ㎎/㎏ HPR (HPR). To induce AGEs, streptozotocin (50 ㎎/㎏) was administered intraperitoneally and after 3 days administrated 100mM methyl glyoxal for 3 weeks.
Results：The oral administration of HPR inhibited AGEs in skin tissues compared with PR. The increased reactive oxygen species (ROS) levels in the serum were diminished by HPR treatment. The analyses of kidney and skin tissues proteins indicated that HPR treatment effectively reduced AGEs related protein levels as compared to that by PR treatment. Also, HPR decreased anti-oxidant related protein levels in skin tissues such as catalase, glutathione peroxidase. Moreover, it inhibited the reduction of COL1A2 by decreasing MMP-1.
Conclusion：Based on these results, it was suggested that PR and HPR could have Improving effects on wrinkle formation. These evidences provide useful information for the development wrinkle formation treated agent.
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KEYWORD
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Paeoniae radix, Advanced glycation end product (AGEs), Collagen, Wrinkle
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